Years before the NBC medical drama "ER", there was a sitcom called "E/R" (note the slash) that was set in an emergency room.
I can think of four performers who were on both shows. George Clooney is the only one who was in the regular cast of both, and Mary McDonnell (who is now on "Grey's Anatomy") was a cast member on slashy "E/R" and a guest star on no slashy "ER". Luis Avalos (always best remembered to me as a cast member from "The Electric Company") and Conchata Ferrell were cast members on the comedy and each did one episode of the drama.
Warner Bros., if they really want to mess with Sasquatch, should bring as many of the old "E/R" cast as they can to one of the final episodes of "ER", which is ending up its 15-year-run in March.